Pyometra in Dogs and Cats: Causes, Symptoms, and Treatment

Priorty Check In
Two black cats are sitting next to each other on a white background.

Pyometra is a serious and potentially life-threatening infection of the uterus that affects unspayed female dogs and cats. It occurs when bacteria, most commonly E. coli, enter the uterus after a heat cycle and multiply due to hormonal changes in the uterine lining. As the infection progresses, the uterus fills with pus and can lead to sepsis, kidney failure, or even death if left untreated.


According to the American Veterinary Medical Association (AVMA), around 25% of unspayed female dogs will develop pyometra by age 10. Recognizing the signs early and seeking treatment from an emergency vet can dramatically increase survival rates and prevent serious complications.

Cases We See


Vomiting

Diarrhea

Coughing

Urinary tract infection (UTI)

Straining to urinate

Blood in urine

Black tarry stool

Blood in stool

Trouble breathing

Anal gland abscess

Facial abscess

Broken nail

Foxtail in paw, ear, or nose

Ear infections

Ear hematomas

Eye infections

Allergic reaction

Upper respiratory infections

Minor wounds

Lacerations

Hit by car situations

Skin allergies

Skin infections

Limping

Loss of appetite

Loss of balance

What is Pyometra?


Pyometra is more than just an infection. It's a critical medical emergency that develops silently and progresses quickly, especially in unspayed females. Knowing what causes it gives you the power to act before it becomes life-threatening.

  • Hormonal shifts after heat cycles cause uterine changes. Elevated progesterone levels prepare the uterus for pregnancy. Without pregnancy, the lining becomes thickened and vulnerable to infection.
  • A thickened uterine lining traps fluid and bacteria. Repeated cycles without conception create a cystic uterine lining, which promotes bacterial growth.
  • The infection causes the uterus to fill with pus. As bacteria multiply, your pet's immune system becomes overwhelmed, leading to toxin buildup and systemic illness.

Unspayed females over five are at the highest risk. Middle-aged to older dogs and cats are especially vulnerable, though it can occur at any age after sexual maturity.

 Open vs. Closed Pyometra

There are two types of pyometra; knowing the difference can help you recognize symptoms faster and take immediate action.

  • Open Pyometra: The cervix remains open, allowing pus to drain. You may notice a yellow, green, or bloody discharge with a foul odor. This discharge makes it easier to catch early.
  • Closed Pyometra: The cervix is sealed, so pus and bacteria remain trapped inside. This is more dangerous because symptoms are less obvious, and the risk of rupture and sepsis is higher. Closed cases often show internal signs first. Look for abdominal swelling, lethargy, or collapse. These are red flags that require urgent veterinary attention.

Symptoms of Pyometra


Recognizing the symptoms early can give your pet the best chance at recovery. While dogs often display clear warning signs, cats tend to hide their illness until it's advanced.


Pyometra Symptoms in Dogs

Early Signs:

  • Lethargy or weakness. Your dog may sleep more, avoid play, or seem uninterested in usual activities.
  • Loss of appetite. A sudden refusal to eat or decreased interest in meals may indicate discomfort or infection.
  • Increased thirst and urination. Pyometra can strain the kidneys, leading to excessive drinking and frequent urination.

Advanced Symptoms:

  • Vomiting or diarrhea. These symptoms suggest toxin buildup or systemic infection.
  • Swollen abdomen. Especially common in closed pyometra, the belly may look bloated or feel firm.
  • Bloody or pus-like vaginal discharge. Seen in open pyometra and should prompt immediate vet care.
  • Fever or low body temperature. A fever signals infection, while a drop in temperature can mean shock.


Pyometra Symptoms in Cats

  • Subtle behavioral changes. Your cat may groom less, hide more, or act less socially.
  • Vomiting and increased thirst. These may indicate internal infection or early kidney involvement.
  • Abdominal swelling. It may be hard to detect but can signal closed pyometra.
  • Vaginal discharge (open pyometra). If visible, it's a strong indicator of infection.
  • Refusal to eat or hide. Sudden changes in appetite or isolation behavior can mean your cat is in pain.


Key Differences: Cats vs. Dogs

Category

Dogs

Cats

Symptom Visibility

Clear symptoms (thirst, discharge, swollen belly)

Subtle signs, often unnoticed early

Progression

Rapid with visible discomfort

Gradual and silent, high risk of delayed detection

Behavioral Changes

Whining, restlessness, aggression when touched

Hiding, less grooming, reduced interaction

Response to Infection

Loss of appetite, agitation

Refusal to eat, avoiding contact, litter box changes

Activity Level

Hesitant but still responsive

Withdrawal from routines, avoids jumping or play

Diagnosis and Treatment of Pyometra


If you suspect pyometra, don’t wait. Early diagnosis and treatment are critical. At Lifeline, we use advanced diagnostic tools and immediate intervention to protect your pet’s health.


Diagnosis

  • Physical Exam: We check for signs like fever, dehydration, abdominal pain, and discharge.
  • Blood Tests: These help identify infection severity and evaluate organ function, especially the kidneys.
  • Ultrasound or X-ray: Imaging confirms whether the uterus is enlarged and filled with fluid and helps determine whether it’s an open or closed case.


Treatment

  • Emergency Surgery (Spay): The most effective treatment is surgical removal of the infected uterus and ovaries. This eliminates the source of infection and prevents recurrence.
  • Medical Management (Selective Cases): Used rarely in breeding animals. Involves antibiotics and hormones, but recurrence is likely.
  • Supportive Care: Includes IV fluids, antibiotics, and pain control to stabilize your pet before and after surgery.

Delaying treatment can lead to rupture, sepsis, or death. If you notice symptoms, contact an emergency vet immediately.

Surgeries We Provide


Abdominal exploratory

Bite wounds, lacerations

C-section

Cystotomy

Digit amputation

Enucleation

Gastric Dilatation Volvulus (GDV)

GI foreign body/ obstruction

Limb amputation

Pyometra

Splenectomy

Tail amputation

Prevent Pyometra in Dogs and Cats


The best way to prevent pyometra is by spaying your pet. This simple surgery permanently removes the risk of uterine infection and other reproductive issues.


Benefits of Spaying

  • Prevents pyometra and reproductive diseases. No uterus means no infection risk.
  • Eliminates heat cycles. Say goodbye to unwanted behaviors like vocalizing, marking, or restlessness.
  • Reduces cancer risk. Especially if done before the first heat cycle.
  • Prevents unwanted pregnancies. Helps control the pet population and keeps your pet safe from birth-related risks.
  • Supports long-term health. Spayed pets live longer, healthier lives with fewer hormone-related illnesses.

Best Time to Spay

Pet Type

Recommended Timing

Cats

4–6 months, before the first heat

Small/Medium Dogs

~6 months, before first or second heat

Large Breed Dogs

12–18 months, based on growth and health

Recovery After Pyometra Surgery


After successful pyometra surgery, your pet's recovery depends on attentive care and a calm environment. Most dogs and cats respond well within a few days, but their immune systems may still be vulnerable after such a severe infection. Following your veterinarian's post-operative instructions is essential to ensure a complete and safe recovery at home.


Post-Operative Care Tips

  • Incision Monitoring: Check your pet's incision daily for any redness, swelling, or discharge. Contact your veterinarian immediately if the site appears irritated or begins to open.
  • Activity Restriction: Keep your pet calm and limit their movement for 10 to 14 days after surgery. Avoid stairs, running, and jumping to prevent strain on the surgical site.
  • Follow Medications: Give all prescribed medications, including antibiotics and pain relief, precisely as directed. Even if your pet seems to feel better, complete the entire course.
  • Nutrition and Hydration: During the first few days, offer small portions of bland, easily digestible food. Ensure fresh water is always available, especially if your pet has vomited or had diarrhea before surgery.
  • Quiet Recovery Space: Set up a soft, quiet space away from household noise and activity. This will help reduce stress and encourage proper rest and healing.


Recovery Timeline

  • Initial Recovery (2–3 Days): Most pets begin showing improvement, such as returning appetite and energy, within the first few days after surgery.
  • Full Recovery (2–3 Weeks): Complete healing typically occurs within two to three weeks. Follow-up visits may be recommended to ensure the incision is healing correctly.
  • Additional Monitoring (If Needed): If your pet had impaired kidney function before surgery, your veterinarian may suggest additional blood work or check-ups during recovery.

If your pet refuses to eat, remains lethargic, or shows signs of discomfort, such as whining or guarding the abdomen, do not wait. Contact your emergency vet or return to Lifeline Animal Urgent Care for immediate evaluation and support.

Lifeline Animal Urgent Care's Emergency Vets Can Help


At Lifeline Animal Urgent Care, we're equipped to handle urgent cases like pyometra without delay or confusion. Our Oceanside facility is designed specifically for dogs and cats in critical condition, with on-site diagnostics, same-day surgical capabilities, and a team trained in fear-free techniques to reduce your pet's stress during evaluation and treatment.

We provide:

  • Rapid diagnostics with immediate imaging access
  • Our in-house ultrasound and X-ray systems help confirm pyometra on the spot, allowing our team to act quickly before complications escalate.
  • Timely surgery from experienced veterinary surgeons
  • We perform emergency spay procedures in our clinic, minimizing the need for transfer and giving your pet the best chance at a safe recovery.
  • Personalized post-surgical recovery guidance
  • After surgery, we walk you through detailed at-home care, follow-up needs, and any medication your pet may require for a smooth recovery.
  • Clear communication every step of the way. Our multilingual team speaks Spanish, Japanese, and Tagalog to ensure you feel informed, understood, and supported throughout your visit.

Open daily from 12 PM to 10 PM. If you suspect pyometra, call Lifeline Animal Urgent Care. We're ready to help your pet get the care they need right when they need it.

Avoid The Waiting Room

Join The Waitlist Or Call Before You Come

We understand how stressful it can be to wait with a sick or injured pet. That’s why we encourage you to fill out our waitlist form or call ahead to minimize your time in the waiting room. We’ll be in contact with you as soon as we have availability.